[F Te antKe]

Crossfire,
"I also go max number of opponents and no neutrals."
I have read a few places that you should minimize the number of AIs. When there are too many of them they end up fighting among themselves till you reach Mega Evil Empire. I’m not sure what the Number / size of quadrant is. I usually play with 6 TDM AI in a small quadrant.
Some of the handicaps you can give yourself:
Only use Counter Intel. – I have read the AI just does not do very well with it. I have crushed the AI using it.
Don’t use Fleet or Ship training facilities
Invade planets instead of glassing them. It is a lot harder.
Don’t trade with them
Only colonize one Planet type
Only play simultaneous games

I’m sure there are more.
Any body else? Is there a list at the Encyclopedia?