[Chronon]

For science fiction, my vote (if we're excluding SEIV of course) would be for Sid Meier's Alpha Centauri. If they had just made one more patch, I would still be playing it.

For wargames, I like Combat Mission - an excellent blend of turn-based tactics and real-time action. If SEV executes tactical combat in the same general way (give ships or Groups orders, click "go," watch action, repeat) I'm all for the real-time turn-based hybrid.

PS. Personally, I don't understand the fuss about real-time combat. We essentially have that in SEIV with strategic combat in simulaneous games: give orders, watch action.