[Chris Byler]

The problem with VQ is that she can wear a variety of protective items and cast protective spells, making her very hard to damage; and then if she is damaged (probably for a small amount) she gets it back the next round from life drain.

If she has astral, even very high astral, she can be stopped by magic duel (backed by Banner of the Northern Star, Power of the Spheres, and potentially communion). If she brings her own banner carrier and/or communion slaves, kill them first.

If she doesn't have astral, even 20 MR won't stop a gang of mages spamming Soul Slay forever. You could do suicide runs with Inner Sun (How much damage does it do? Is there an MR save? Is it elemental?)

Is the VQ inanimate, and if so, is she affected by Shatter? (100 PREC, no MR save, 35+ armor negating damage... ouch!) Gifts from Heaven is hard to cast (Evo 5, Earth 3 Astral 1), but does 150 non-elemental damage with no MR save - if it hits. And of course, if she is given fire susceptibility, it'll be harder to avoid Holy Pyre, Just Mans Cross, Flambeau and Angelic Host. Dust to Dust and Wither Bones are effective if they hit, but require Death magic.

You can horror mark her and call horrors, but I don't know how effective that would be against a really super supercombatant. AFAIK you can't call Doom Horrors or the King of the World. (Call Doom Horror would make a cool Blood 9 spell...) Although maybe if you have enough people use Hell Power, you'll get the KotW to show up on his own.