[Alneyan]

Do not forget the Almighty Weapon of Incredible Devastating Potential, Whose Name Should Not Be Spoken Aloud. This wonderful weapon, truly one of its kind, is a marvel of technology, and the greatest achievement of mankind. Nobody else can discover such an advanced device, least of all an AI.

So, this panacea of all troubles is as follow. When faced with a powerful AI, and if your pride cannot be tarnished by the infamy of defeat, you should take over their Empires and execute their ministers. This will completely destroy the "intelligence" part of AI, leaving them with a bunch of planets and warships, but no ability to actually do anything useful with them.

Therefore, if you are losing a game pretty badly, I urge you to put this awesome weapon to good use. Prevent the AI from thinking, and you have won! If you still manage to lose, you should let the Council of Evil Overlords know about your failure, so that they will be able to retire you quickly and effectively.