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Thunder strike, astral fires, falling frost, frozen heart, raise skeletons + drain life or drain life + raise skeletons depending on what order you want them in, bladewind etc. Those are all effective spells against Devils.
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Thunder stike works quite well on devils. Astral fires not so well, MR negates and it's hard for pythium to get access to it, falling frost is ok but does not really kill devils all that well ( it really should don't know what goes wrong ), Blade wind works decently but against it is hard for Pythium to gain access to it, raise dead/drainlife works well against anything, but is hard for pythium to gain access to it.
Of those suggestions the best two for Pythium are Thunderstrike and falling frost. And thunderstrike has a cool sound effect.