About the only use I have for missles anymore is for early game scout frigates. People around here have developed a nasty habit of setting their colony ships to ram instead of waiting patiently for my DUC frigates to blow them away. I have a strict policy that any ship captain stupid enough to get himself killed by an unarmed ship gets his purple heart posthumously revoked.
A missle frigate set to max range does a nice approximation of the missle dance in simultaneous games and about half the time in my experience will stay far enough away from the colony ship to not get rammed into oblivion. They also do nicely for glassing those border colonies before the other guy gets his mine fields up or his PDC WP's built.
Definetly an early game weapon only against a human player.