[Taqwus]

If they can do more damage than is restored per turn, perhaps. A well-equipped air queen with mirror image might be hard to hit.

There's always Pan CW for being hell on enemy SCs; defense goes down with many attacks on the same turn, and sleep vines get 3 per with each hit delivering armor-negating unresistable fatigue damage... and there's no attack vs. defense roll on those already unconscious. Anybody unconscious and facing more sleep vines is therefore likely to never wake up.

In the more general case, the aforementioned elf banes, solar lances, moon blades, even bane blades and banefire archers (decay, and potentially many MR checks per salvo) and banefire (massive unresistable damage with a chance of decay) should help. Curse should help versus those relying on life draining instead of regeneration or recuperation, as a blind SC won't fight very well.

In extremis, I wonder how many Crystal Mages it would take to reliably slap one with Gifts from Heaven. 150 points of pure physical damage is not to be laughed at.