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We've already discovered organisms that live and breed in acid pools (something like that anyway)
So the theory that all life must be Earth life (ie. oxygen & water) has already been proved false
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Well, even the creatures that exist under (for us) extreme conditions on Earth are still based on carbon, water, nucleic acids, etc. In other words, they're variations on a theme, but not a new theme.
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There is no doubt in my mind that life can exist out there, its just a case of whether sentient life has yet to develop out there that I wont make up my mind until its proven either way
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As long as even a little corner of the universe remains unexplored, the existence of alien life/sentience can't be disproven. So despite the skepticism of some, an enthusiast for ET's can only be proven right, never wrong.
