[FrankTrollman]

Yeppers, Regeneration kicks Luck hard when it comes to beating battle afflictions. Of course, Luck applies against Soul Slay and Regeneration does not.

As for a Pangean build, sure. Pangea has access to virtually limitless Nature and a reasonable amount of Blood Slaves and Death Gems. As such, you might want to make a build of:

Blood Thorn
Vine Shield
Horror Helmet
Hydra Skin Armor
Boots of the Messenger
Lifelong Protection
Cat Charm

You end up with no Quickness, but you have some Fear going, and the Vine Shield combines well with the Lifelong Protection. Unfortunately, Pangea is not very good at item crafting, since both Nature and Death are craptastic at making equipment for supercombatants (except for the Hydra Armor/Ring of Regeneration).

-Frank