Ya, I normally use tactical, so I can use the weapon killers where they will actually kill weapons. Like I can have all my ships in range target an enemy PDC ship so any fighters I'm using don't get pulverized. If it's a ship with only uber-sized guns, I'm not going to waste my firepower on it.
Sometimes too I'll ditch the weapon killers on my attack ships and just put them on defense ships. Their purpose is basically to kill if possible, and if not, severely maim, attackers. Take out repair ships and you effectively kill an invasion while reinforcements arrive. Would be nice if I could have more control over the combat AI so I could use this strategy in multiplayer (once I figure out what the heck is wrong with my computer
)