Well, I will be able too...I have [me and my brother to be correct] the best hardware available atm, including 2 7800 video cards in SLI. This is only because our parents are really so cool about everything, also I play FPS games too, so I need a good system for those.
..but yes, I think most of the people wont be able to play these games on the best gfx settings...its a shame, however, hardware prices will be much lower for these current hardware compoments [like the 7800 cards], when this game gonna be released.