[Suicide Junkie]

First thing:
Don't play stock. Get Kwok's balance mod (AKA KwokStock)

You probably need to set the video memory to safe mode (in the video setup on the very first splash screen)


Those two things should relieve a lot of your issues.
Setting the Hotkeys to something you're used to, and shift-click on numbers and the design screen are big things for the UI side.