[Suicide Junkie]

In order for the game to be playable, the only thing you need to do is to run my AI Patcher on each of the races you add to P&N. ("Engine factor" setting must be 45 to prevent RCEs!)

The other prolem you will likely have is that the TDM races will not build enought rad extractors on their planets. They have been tweaked to the original game, which was quite mineral-intensive.
In P&N, Rads become more important as the game progresses, mainly in high level engines and shields.
From games I've played, I would estimate an even need for both resources.
If there are any AI modders out there who could suggest a straightforward way to do that, please speak up!

On the other hand, once the AIs are patched, you could change P&N to reduce rad costs instead of increasing AI rad production...
The largest rad costs are engines and phased shields. Reduce the rads by 75% or so, and add that difference to mineral cost.
This method may be easier, but you will be falling back to a one-resource game.

I may be able to make an AI patcher to properly diversify the AI's resource gathering, but I'll have to see what the AI guys say.