Re: Best defense or cure against disease?
On prevention, there's two avenues. Battle and other.
On other...
1). Have enough supplies. Keep a bag of wine on hand in your castle garrisons. Be cautious when invading Ermor, or being a cold nation invading a hot, death scale land.
2). Leprosy - have a decent magic resistance.
3). Kill anybody likely to get Burden of Time up, especially death heavy pretenders leading nations with no death mages and plenty of years left till old age.
4). Don't play an a nation with mages with old age. If you do, growth scales can mitigate the effects somewhat.
When it comes down to the battlefield, however, there's not much you can do to prevent it other than reduce damage taken. I do hear regeneration does reduce the chances of gaining afflictions, as well.
I doubt this has been useful, but you did ask.
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