[Suicide Junkie]

IMO, SE4's graphics are superior.
They are only as big as they need to be, don't block your view, and everything is always perfectly legible.

Snappy and responsive too, since the screen only has to be drawn once instead of continuously.

SE5's pictures are bigger and prettier, and the 3D models are nice, but they don't help gameplay at all, and often make it hard to see and read things.
Oh, how I long for 2D text overlays whenever I look at the system or combat views.