[thejeff]

When you choose a mod it is active for game or pretender creation. After a game has been created, it will always try to load the mods it was started with.

So, no. There's no need to turn mods on and off when taking turns. As long as you have them installed everything will work fine.

The only potential problem is if you have a mod turned when you create your pretender that actually changes the pretender you make. It's safest to have all the game's mods, and no others, on when making a pretender.