[Acenoid]

1)
if you have other apps running at the same time but you only use dom3 you can try to increase the process priority (open task manager from (ctrl + shift + ESC) then you select the dom3.exe in the processes tab, right click "process priority" -> then try above normal or high. Do not use "realtime".

2)
Also helps to defragement your harddisk

3)
besides video drivers other drivers could be outdated. check all of them. Update windows with all patches.

4)
check the autostart folder and the registry run / run services maybe there is software being launcehd at windows startup that you do not need.

5)
if the above doesnt help: try to disable your antivirus program while playing

6)
maybe you computer is also infected with malware ? try scanning it with a bootable antivir cd you got from a friend. (plenty of instruction are available on the net if you do not know how to create such a cd). Furhter in this direction you could scan it with "hijack this" for malicious software - there are online sites who automatically check the (complicated) program report.

Hope this helps.