I agree w/ DonCorazon that trying to attract boardgamers might be more satisfying than trying to get MMORPG players. Boardgamers seem to be (IME) more interested in strategy, deep games, and games where the ideal strategy and tactics depend on what (you think) your opponent is doing.
I'm not sure all boardgamers will like Dom3, because there are some big differences between the way boardgames and computer strategy games have developed in the past few years, but I think making them aware of it won't hurt. And, of course, all boardgamers are used to MP-only play, because for most boardgames, that's all there is.
