Unistall it, be sure the directory is completely removed, and reinstall.
Be sure that your copy of the patch is a good copy. I would download it once again to be sure.
Your patch should be Version 1.49
If that does not work, keep posting in this forum until someone answers you, or email Aaron directly. He is usually pretty good about getting back to people in a couple of days. (He is often very busy.)
Additionally, make sure you have enough space on your hard drive. (Not listed in your system report)
Finally, just install the game, and see if it works ok without updating it. Then update it. Then try it. If it crashes before the update, then you'll know you have a bad disk, if it crashed after the udate, then you'll know it was the update that killed the game.
Also, many of the new addon's are for GOLD. I do not know if they will work in SEIV 1.49 or not. Both Versions of the Trek Races are posted at PBW site. Pre-Gold, and GOLD.
Best of luck, and please keep the faith, the game is worth a little trouble.
Once its running you'll have a new addiction.