[PvK]

Break Formation / Max Range works well for missile retrograde in strategic combat. If your ships also have shorter-ranged direct-fire weapons, though, they will try to use those while the missiles are re-loading.

The main disadvantage is human opponents will tend to deploy PDC more vigorously than the AI after they notice you have a lot of missile ships (or even before).

Tailor your tactics to your opponents.

PvK