[Ewierl]

Nope. Luck and curse aren't really opposites. Luck means all damage (except insta-death, IIRC?) has a 50% miss chance; Curse means all damage has x2 chance of dealing afflictions.

In terms of affliction accumulation, they do cancel out over time (half the hits, but twice the affliction odds on each)- but Luck negates damage, not just the afflictions, so Luck+Curse is a better state than "neutral".