Yes, if you do;
Code:
orion@universe:~$ dom3 -u [game name]
as launcher command.
or use
--enablemod Nosophoros to enable the mod.
So to start dominions 3 in fullscreen and enable Nosophoros you do;
Code:
dom3 -u --enablemod Nosophoros.dm
You can run dom3 with --help flag in the terminal to see which flags there are available. though no
man dom3
Pretty simple.