Slightly Off Topic, but here I go...
Haven't actually ever thought about using Mother of Serpents as a target for wish, have to keep that in mind
Other than that, Mother of Serpents as pretender chassis is pretty nice if you go for Tartarians in a sort of sneaky way. With high enough D paths she can summon a Tartarian, next turn heal it, then summon another, heal it etc. You won't have lots of Tartarians fast, but you'll be guaranteed to have them all without afflictions
Also, I had in one SP game a 16 strong Knights of the Chalice unit, each with 4 star experience. I had GoH up, and that unit simply did kick butt (but then again, what doesn't in SP...), and I'd really want to see a similar unit in a MP someday