Mandaha has fatigue aura similar to that of Shuten-Doji.
Mage Bane deals 100 irresistible fatigue per hit (or something around that).
Also, Oal Khan's Sceptre has Area Fatigue effect but it doesn't seem too powerful.
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Normal heat/cold penalties are only at level 3
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And IIRC
any amount of appropriate resistance negates this effect, not 50%.
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Being underwater also adds 1 enc.
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...and 3 enc for poor amphibians