[thejeff]

I'd avoid the VQ, especially in vanilla. Far too expensive for what you get.
With Mictlan, take whatever chassis you can cheaply get a W9F9 bless with high dominion. Recruit nothing but mages and Jaguar Warriors, slaughter everything. Go heavy into blood hunting, summon your national sacred summons and continue to slaughter everything. When you get bored with killing things, blood sacrifice everywhere and let your dominion win for you.

It's not quite that simple. It takes a little while to get the hang of balancing blood hunting with income and research. Still, Mictlan is a power and double bless sacreds are very hard for the AI to counter.