[Calahan]

My understanding* is that if you install Dominions to "C:\Dominions", then Windows 7/Vista won't hide the save game files from you like it does when you install it to the suggested default directory. So maybe un-install Dominions at home, re-install to the root of the drive, then patch, then copy the folder to the stick for use at work.

Then for playing at home, either play directly from the stick (which a lot of people do), or just copy the save files from the stick to your home machine (and vise-versa when you want the turn to be available at work)

*(I'm not exactly sure, as I don't use Dominions with Windows 7 or Vista, so I'm going on what I remember seeing posted before on this topic)