I tend to go for a couple heavy tachyon beams to rip apart enemy guns, and then nullspace weapons to rip apart thier ship. Slow reloads, but I can ignore even phased shields AND armor. The reduced damage and range is worth it, because late game I tend to have ships moving 6 in combat and I can get in close as needed, and I only need to get in once before he's unable to fire back with any significant effect.
I prefer to fight by blowing up stars and ripping planets into asteroids. I don't believe in allowing the enemy to reclaim territory and in the late game I get no advantage from taking his turf.
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