[Trajan]

Playing against AI opponents, and using the DevNul mod, I use Spinal Mount Wave Motion Guns, and/or any other spinal mount direct fire weapons that I happen to have researched. I shoot for maximum punch before he can pound the snot out of me with his Talisman accuracy.

Also, I use specialty ships (cruisers and the like) which carry engine destroying, null-space, and warp weapons. I use them in this order and usually end up with an AI opponent with a lot of very damaged and slow or non-moving ships which are easily taken care at a safe distance.

I always assume that I will have losses, but the AI targets my Dreads which are heavily armored and/or shielded, while the specialty cruiser go in and do their jobs.

Cheers!
Trajan