Missfortune seems always a bad idea, its really the least thing i pick. You don't get heroes and no gem events, your temples and laboratories are going to be razed by raze events. But i never tried missfortune3 with Ryleh, iam scarred by missfortune3.
The maps i play are not big and my dominion is usually high set. I do that with BF ulm theme where i can have fortunetellers, but rather prefere good events that give additional gold and gems.