Rather than editing the tech costs, go to the system map, press `, type alltech, press enter then press `. Presto, you've got all your reasearch done.
EDIT: a few more.
Right click on EVERYTHING. There are a number of right-click shortcut menus in every screen that will save you lots of time and effort.
Simiarly, get to know (and change if needed) the keyboard shortcuts. Much faster to hit backspace to cancel an order than wade through a menu.
Play in the highest resolution that gives you decent FPS. The UI elements are a fixed size, so the higher your resolution the less screen space they will take up.