Depleted Uranium cannons can fire at fighters, including the large mounts. Since damage seems to stream over from fighter to fighter, you can do some pretty big damage to fighters. Probably why I've seen some requests to do something about that.
(Perhaps there should be another mod available for Component Enhancement that allows you to change what a particular weapon mount can fire at. Massive DU cannons should have some difficulty targeting fighters, but standard mounts probably should be allowed to.)
Oh, how do you hit fighters with them? You -are- installing Combat Sensors on your ships, right?
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"What do -you- want?" "I'd like to live -just- long enough
to be there when they cut off your head and stick it on a
pike as a warning to the next ten generations that some favors
come with too high a price. I would look up into your lifeless
eyes and wave like this..." *waggle* "...can you and your
associates arrange that for me, Mr. Morden?"