Computer Controlled Ship Mutiny???

[PvK]

Yes, or one of your own race with access could have decided to get rich by giving access to some alien who would pay them or do something they needed done, etc.

[Possum]

If we are talking true AI here, as in Artificial Intelligence, what makes you think it would be any more resistant to treason than a biological intelligence?

Granted, some of the usual leverage factors would not apply (kinky sex, for example).

Drugs, on the other hand, are a possibility. Nobody says a drug has to be chemical in form. Here's an example...