Twiceborn Crone doesn't have much to say...

[AreaOfEffect]

The chance of affliction is equal to the percentage of damage you take compared to your maximum hit points. The crone will likely lose all her hit points at once and be guaranteed an affliction. There are a couple ways to mitigate this result.

First, fight in a zone that is strong in your dominion. Second, equip an item that gives regeneration or cast the spell as it will reduce the total chance of affliction by 1/8.

Good luck.