The most dreadful (random) event?

[ano]

To prevent valuable gem (and especially slaves for non-blood nations) loss events I try to give them to commanders until I need them.
Plague is a real disaster. OTOH it may be quite good if it is late stage and not valuable low-pop province. It generates so many corpses that you can easily raise legions of cannon fodder with Carrion Reanimation.

[Aezeal]

Well getting an event that gives 50 unrest in your capitol on turn one is pretty annoying in MP .. your econ will be effectively crippled more than anything else since it's in your only high income province.. and at the worst possible time