"Dagger of silence" and possibly other questions

[llamabeast]

You can only apply an affliction that a weapon already in the game applies.

To clarify, there are quite a few hardcoded "weapons" which cause a particular affliction. Weapons already in the game use them as #secondaryeffects. You could use one of them too, but you can't make a new one. So, you can definitely cause a Chest Wound or a Lost Eye, but I'm not sure about Mute. The best thing would be to read Edi's database.