I once was in a game against a Talisman player and found a pretty good way of dealing with him. As Geo said, I was able to take some extra risks because our first few battles were decicive in his favor so I wasn't risking much. More like a fighting retreat...
The key in my experiance was that he was using Null Space, Mesons, and some Plasma Torps. I used APB 12's. I designed my ships to maximize their chances to hit and gave them the Max Range/Don't Get Hurt stratagy. I then made some LC and BC's that were just Engine Killers, heavily shielded and as fast as possible. I gave them Point Blank/Don't Get Hurt stratagey. They would fly in, knock out enough engines before either getting turned to scrap or getting away. Then my BB's and DN's would sit out of range of all but his missles and pound on them. I included 2 PDC on each of my bigger ships which were enough at range to eliminate nearly all the missles. And those that did get through didn't penetrate my shields.
Worked great but only because he relied on shorter ranged weapons. BTW, if my engine killers didn't do their job, or weren't present, I either got a beating or we statemated.
So not the best tactic but it kept me from lossing too fast
