It is certainly possible, but no easy task. You have to go through the modified data files of each mod and combine them, manually. I suggest using Highliner as the base, as a lot of items are changed to be useable on fighters and such, due to most "ships" being "fighter" hulls instead.
The AI in Highliner is able to play along? Or it simply don´t work in the Highliner mod?
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Currently Playing:
Megamek (latest dev version with home-made random campaign generator), Dominions 3 (with CBM) and Sins of a Solar Empire (heavily modded)