ME is an unbelievable piece of crap. I was getting 4 or 5 crashes a day when I had this at work. Usually with MS's own software Outlook express. I can't count the hours I wasted before we finally concluded it was ME and not the new computer. I have XP at work now and it works great (although I suspect for my needs 98 would have been a better choice).
I still have ME at home and although it is not as bad as the work incident it does still crash quite often.
A little research on the net told me that ME suffers from major memory leaks resulting in unpredicatable program behavior and crashes