Now Running: Mosehansen Game, Paradise Lost

[Cainehill]

Your armies start picking up afflictions as though diseased. Your commanders and mages start getting afflictions, sometimes even dying right away. And you don't get a useful report that would allow you to see who get the afflictions and whatnot, so every turn you basically need to check every single one of your mages and commanders to make sure they're not diseased or otherwise about to die.

And of course if they die while carrying magic items, the magic items are lost. It's a wonderful spell that causes some players to simply go AI when it's cast because of the sheer aggravation factor the spell produces.

Dominion doesn't help against it. There's nothing you can do to protect your mages or troops - if they're not undead or lifeless, they start dropping like carrion flies.