Well Dominions 3 is of course #1 on my list.
Also Space Empires V is right up there nudging it.
Oblivion maybe if its more like Daggerfall and less like Morrowind.
Im still waiting for my copy of VGA Planets 4 that I pre-ordered years ago.
And Stars-SuperNova.
My choice for unique change-the-world game is called Tranquility (way cool) but I will go look at Spore
I still keep an eye on all the different efforts at re-creating Master of Magic
And Im waiting for more info on that game that Shrapnels pop-up ad mentions. Something about dare to dream?
Gandalf Parker