I dunno, it might ... probably the best way to check is to run a bunch of tests casting leprosy on a mix of regenerating and non-regenerating units with identical MR and count how many get diseased.
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My guess would be that regeneration simply interacts with the actual affliction mechanic, from damage. Leprosy, being a spell that causes a particular effect, that just happens to be classified as an affliction, is probably unaffected by regeneration.