That story about the head of Vecna is hilarious.
I would like to think that not all of us would act like that however. In Dominions, I find that some things can cause me a lot of grief, because simply acting marginally more sensibly would avert the disaster that turns an otherwise wellplayed game into a losing battle.
Purposefully (automatically) doing things that cause permanent wounds is one such thing (if you are relying on that SC or pretender).
The eyes and hearts, etc., were never intended to be used as cursed items. I hope that the game designers will implement the found item going to the laboratory. This should included such items as the arena death match trident, which is also automatically equipped, and cannot be unequipped.
Feel free to implement true cursed items, but make it by design, and allow a remove curse spell (costing astral gems?) to destroy or remove the curse / cursed item.
/Rainbow