I don't believe that one should be creating a pretender/god in the RL. That closes of the possibility to become one! Well, you could also be *playing* one, but we have Dominions for that, don't we? The view of commander/soldier/assasin for your god does give a whole new view to the game.
I also like the idea of a story. To blind the opposing Cyclops that was harassing your homeland with his fiery armies, to destroy the spirit that guided Pythiumian forces past defending armies to destroy your home...

Really, that sounds great! And you can have *16* main targets!
About races and character classes, what about the already-suggested Abysian, Caelumian, Pythiumian etc. with Gladiator, Legionaire, Theurg, Hydra Trainer... for Pythium. Each nation would have some classes unique to them. Crawl-like classes that show what the character has learned in the past but that don't affect what he can (or will) learn might not suite Dominions very well, but adding some of it would not hurt...
About magical sites: many roguelikes have Vaults, known by different names in different games. They are huge rooms filled with many/stronger than usual monsters, often guarding great treasures. "You discover a way to get past the fiery wall, and find a way leading to the Tar Pits. There are two experienced Fire Drakes and a huge Fire Elemental guarding it."
Sorry if these ideas distract you, I don't except you to be far enough to implement any of these yet. I just am quite excited about the idea...
