I mostly buff, and cast non-dmg spells, so I have not seen any big effects. Incinerate, mindburn, frozen heart all kill their target more or less. I haven't used bladewind or other wide area attack spells atm. Only got them in my face
I saw several crushers getting afflictions from jaguars that actually got close to the enemy, but mages might have had an influence on this as well. Mostly chestwounds, but some limps and a cripple. Not that they bother that much. After all their main purpose was to be in the way.