How do I kill a water queen with a medusa shield?

[Baalz]

I find really tough guys tend to go down to fatigue spamming. As far as fatigue goes Stellar cascades, heat aura, thunderstrike, pillar of fire etc. will circumvent the MR, defense, protection, and MR and regen doesn't help. Additionally fairies, manikins, etc. don't completely circumvent it, but work pretty well in numbers. She's got reinvig, but not that much, and once she's passed out most any half decent thug should be able to pound her into the ground. (just give him good MR). Presumably she's buffing herself a couple times and with that encumbrance she'll be more than halfway passed out before you do anything...