The unbeatable combination is it out there?

[PvK]

If you can set up a heavy warp-point defense with appropriate equipment, or always run to the far side of warp points and get him to chase you, the point-blank combats with you getting the first round can tip the scales against the talisman.

If you have some peacetime to build up, consider lots and lots of drones, fighters with shields, and mothballed kamikaze ships.

If you don't have other opponents, and his designs mostly use talismans, remember not to waste resources on ECM.

Outmaneuver his fleets strategically with planet-busters, raiders, troop transports, minelayers, and hit planets and cause riots, getting him to split up his fleets.

Start a nova somewhere appropriate.

Most effective though, is probably to use diplomacy - get everyone else convinced they must be ganged up against in an organized and ruthless fashion.

PvK