Those silly satellites...

[Suicide Junkie]

Strat:
I don't see any connection there.
My idea is to remove the autofire ability. That's what makes PD so crazy; with autofire, it is like minesweepers. You kill the first X missiles for free, guaranteed

By removing autofire, your ships actually have to work to shoot down missiles, and the inefficient cooperation between ships means some of the missiles get through, even when you have tons of PDCs. You'd have shots ready, but be unable to use them in time.

[Ragnarok-X]

Then again, removing autofire/point-defense ability would result in guaranted kills, since some missiles might be able to reach a ship within one turn, while the enemy would not even the chance to fire at them (turn 0: out of range, turn 1: missile has hit).
Of course this wouldnt happen in tactical where you can control your ships, but in strategical there is no way to tell your ships to keep a certain distance to missiles.